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Investing
in healthy lifespans

quadraScope invests in biotech companies working to dramatically extend human healthspan by targeting the hallmarks of aging.

Hallmarks of aging

Biogerontology is the new science that aims to extend human healthspan by addressing the biological basis of aging. It revolves around the concept of the Hallmarks of Aging, a framework introduced in 2013 by López-Otín et al. and further expanded in the paper Hallmarks of Aging: An Expanding Universe in 2023. The hallmarks of aging are shown below.

Genomic instability

Accumulation of DNA mutations due to failure of DNA repair mechanisms.

Telomere attrition

Shortening of the protective caps at the ends of chromosomes, leading to DNA damage and senescence.

Epigenetic alterations

Modifications in the way DNA is stored, read, and expressed, without altering the gene sequence.

Cellular senescence

Senescent cells are no loner able to divide, cannot die, and contribute to inflammation.

Mitochondrial dysfunction

Mitochondria, the energy-producing structures within cells, become leaky and inefficient.

Stem cell exhaustion

A decline in the number and function of stem cells, which are responsible for maintaining and repairing tissues.

Deregulated nutrient-sensing

Disruption of the mechanisms that control metabolism, utilization of nutrients, and  energy balance.

Loss of proteostasis

Failure to maintain protein quality and function, leading to the accumulation of damaged proteins.

Disabled macroautophagy

Decreased ability to break down and recycle damaged or unnecessary cellular parts.

Altered intercellular communication

Communication systems between cells become unstable and cells lose the ability to work together effectively.

Chronic inflammation

The immune system stays persistently active even when there is no infection to fight or injury to repair.

Dysbiosis

Unbalanced populations of microorganisms that live in the human body.

Our portfolio

We have a diverse, synergetic portfolio led by serial entrepreneurs and renowned scientists.

Rejuvenation of the immune system using the secretome of partially differentiated immune system progenitor cells.

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Nanoparticles (NaNots) that capture and remove circulating harmful proteins.

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Drug discovery platform using organoids exposed to microgravity and radiation as models of accelerated aging.

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Cholesterol degradation platform to reverse atherosclerosis.

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Franchise of clinics specialized in personalized rejuvenation services.

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User-friendly machine learning platform to analyze and share biological data.

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Treatments that boost the immune system’s capacity to clear senescent cells.

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Team

We are a women-led team with a strong track record of taking new ventures from inception to profitable exits, including a 12x exit, and deep understanding of the emerging longevity science and market.

Fiona Miller

Fiona Miller

Managing Partner
José Navarro-Betancourt, MD, PhD

José Navarro-Betancourt, MD, PhD

Scientific Director & Partner
Nir Barzilai, MD

Nir Barzilai, MD

Advisor
Miri Polachek

Miri Polachek

Venture Partner
Aubrey de Grey, PhD

Aubrey de Grey, PhD

Advisor
Daniel Fylstra

Daniel Fylstra

Venture Partner
Diane Seimetz, PhD

Diane Seimetz, PhD

Advisor
Reason

Reason

Advisor
Carmela Abraham, PhD

Carmela Abraham, PhD

Advisor
Lan Clark

Lan Clark

Venture Partner
José Cordeiro, PhD

José Cordeiro, PhD

Advisor
Frank Wellens

Frank Wellens

Venture Partner

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